I want to preface this with the following:
- I am not a complete anti-vaccine person. I believe the schedule for babies and children has gotten out of hand with diminishing returns and increasing harm. Why newborns would need shots for Hep B (I haven’t even had that one) before they leave the hospital, I have no idea.
- Additionally, I think that the carriers and additives that are used in vaccines and shots (there used to be a difference until they changed the definition) have not been tested for safety in a cumulative situation.
- Also, now that we know that ‘safety trials’ do not use a true placebo (inert solution), then those tests are, IMO, tainted and invalid.
- I think that the autism study (debunked) might have been a red herring to deter any further study of the effects of shots on babies.
All that said. A new study actually looks at newborns and have found a possible link between shots and Sudden Infant Death Syndrome due to the cumulative effect of exposure to components in shots and vaccines.
Cumulative exposure to vaccine excipients
Although vaccine excipients are present at reduced or trace levels per dose, cumulative exposure from multiple vaccines administered in early infancy could exceed safe thresholds in infants with CYP450 polymorphisms 15. While direct studies on vaccine excipients and CYP450 metabolism are limited, research on chemically similar compounds suggests potential enzyme interactions 19. The immaturity of metabolic pathways during infancy may reduce the capacity to detoxify or eliminate vaccine excipients, raising concerns about cumulative impacts 14, 15, 19.
Table 4.
Vaccine excipients potentially impacting CYP450 enzymes in infants (<12 months) and fetuses.
Vaccine(s) Excipients1 that potentially impact CYP450 enzymes CYP450 enzyme(s) involved Metabolic role DTaP, HepB, Hib, PCV Aluminum hydroxide/phosphate2 CYP1A2, CYP2D6,
CYP3A4, CYP2C9Cytokine-mediated CYP450 downregulation. Rotavirus, MMR, Varicella Live attenuated rotavirus CYP1A2, CYP2D6,
CYP3A4, CYP2C9Immune activation leading to cytokine-mediated CYP450 downregulation. COVID-19 Vaccine Lipid nanoparticles (LNPs) CYP2C19, YP3A4,
CYP2E1LNP-induced cytokine release may suppress CYP450 modulation. Hepatitis B (pregnancy) Aluminum hydroxide/phophate2 CYP1A2, CYP2D6,
CYP3A4, CYP2C9Indirect immune modulation. COVID-19 (pregnancy) Lipid nanoparticles (LNPs) CYP2C19, CYP3A4,
CYP2E1Immune modulation and potential metabolic effects.
1Excipients not included in this table: Polysorbate 80 and/or Formaldehyde found in trace amounts in DTaP, HepB, PCV (Pneumococcal conjugate vaccine), RV (Rotavirus Vaccine), and vaccines given during pregnancy—TdaP, Inactivated Influenza (IIV), and COVID-19.
2Refer to CYP450 interactions described below in the “Reevaluating Infant aluminum exposure” section.
What the study basically says is that babies lack the enzymes necessary to detoxify from the additional ingredients in vaccines and, in essence, are overloading their systems and that can lead to death.
Vaccines are a cornerstone of modern medicine, significantly reducing morbidity and mortality worldwide. Their administration in infants, however, requires consideration of physiological maturity. Cytochrome P450 (CYP450) enzymes, crucial for drug metabolism, are immature at birth and mature over time 1. While these enzymes metabolize approximately 80% of clinical drugs 2, 3, the potential influence of CYP450 enzymes on the metabolism of vaccine excipients in infants remains under-investigated. This study examines how CYP450 enzyme immaturity and variability may influence the metabolism of vaccine excipients and its relevance to immune response and safety outcomes.
Babies and children are not just small adults. That’s why they can’t take certain medications and require different dosages or formulations. Why the same care and protocols involved in trials and administration of oral medications is not applied to vaccines and shots, I do not know.
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